The 35-year-old, likely appearing at the tournament for the last time, has scored three goals across their four games so far.
Argentina came into this World Cup as favourites but look like they’ll need Messi to once again work his magic if they are to leave Qatar with silverware.
Messi is yet to win the tournament and from here on out, every game at the World Cup could well be his last on the biggest stage of all.
MORE: Which teams have qualified for the World Cup quarterfinals?
When is Messi’s next World Cup match?
Messi and Argentina will next be in action on Friday, December 9 when they take on the Netherlands in the quarterfinals.
Argentina beat Australia 2-1 last time out with Messi opening the scoring to notch his third third goal of the tournament so far.
Netherlands look set to offer Argentina a stern test having themselves beaten the USA 3-1 in the Round of 16 and are yet to lose in Qatar.
Argentina match schedule and results
Argentina knockout round schedule because they finished 1st in Group C
*Only in event of defeat in semifinals
Argentina vs Netherlands live stream, TV channel
This quarterfinal clash will be played at Lusail Stadium. Here’s how you can watch all the action in some of the major global territories.
MORE: Watch every World Cup match live with fuboTV (U.S.-only free trial)