Harden was chose by Oklahoma City coach Scott Brooks, who will coach the Western Conference. Harden played for Brooks for three seasons before being traded to the Rockets.
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Bryant's spot on the roster was taken by New Orleans Pelicans forward Anthony Davis, who will represent the host city.
Originally, Bryant and the Golden State Warriors' Stephen Curry were voted in as starters for the Western Conference. Other starters in the game include Kevin Durant, Blake Griffin and Kevin Love.
